Article
High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia.
Cytokine - 21 May 2004
Wirz Sebastian A, Morale Maria C, Marchetti Bianca, Barr Alasdair M, Sotgiu Stefano, Rosati Giulio, Pugliatti Maura, Sanna Maria Vittoria, Giliberto Orazio, Bartfai Tamas, Conti Bruno
Abstract excerpt
The G to A single nucleotide polymorphisms (SNPs), at position -376, -308 and -238 in the promoter of the tumor necrosis factor alpha (TNF) gene, have been independently correlated with numerous diseases. Alleles TNF(-376A) and TNF(-238A) are normally found throughout the world with very low frequencies. We investigated the frequency of these SNPs in Sicilian subjects hospitalized after traumatic brain injury and...
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