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Article

SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.

The Journal of investigative dermatology - 1 Apr 2012

Celli Anna, Mackenzie Donald S, Zhai Yongjiao, Tu Chia-Ling, Bikle Daniel D, Holleran Walter M, Uchida Yoshikazu, Mauro Theodora M

Abstract excerpt

Darier's disease (DD), caused by mutations in the endoplasmic reticulum (ER) Ca(2+) ATPase ATP2A2 (SERCA2b), is a skin disease that exhibits impaired epidermal cell-to-cell adhesion and altered differentiation. Although previous studies have shown that keratinocyte Ca(2+) sequestration and fluxes...

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Source

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Identifiers

PMID: 22277942
DOI: 10.1038/jid.2011.447
PMCID: PMC3305850

Genes

SPHK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22277942-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.PMID 22277942Read ↗

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