Article
The role of Clock in the plasticity of circadian entrainment.
Biochemical and biophysical research communications - 11 Jun 2004
Udo Ryuta, Hamada Toshiyuki, Horikawa Kazumasa, Iwahana Eiko, Miyakawa Kazuko, Otsuka Kuniaki, Shibata Shigenobu
Abstract excerpt
The mammalian circadian clock lying in suprachiasmatic nucleus (SCN) is synchronized to about 24 h by the environmental light-dark cycle (LD). The circadian clock exhibits limits of entrainment above and below 24 h, beyond which it will not entrain. Little is known about the mechanisms regulating the limits of entrainment. In this study, we show that wild-type mice entrain to only an LD 24 h cycle, whereas Clock...
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