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Article

The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jun 2004

MacPhee Iain A M, Fredericks Salim, Tai Tracy, Syrris Petros, Carter Nicholas D, Johnston Atholl, Goldberg Lawrence, Holt David W

Abstract excerpt

Previously, we reported that, at 3 months after renal transplantation, individuals with CYP3AP1 genotype CYP3AP1*1 (linked to CYP3A5*1 and strongly associated with expression of CYP3A5) required twofold higher doses of tacrolimus to achieve target blood concentrations than individuals with the genotype CYP3AP1*3/*3 (CYP3A5 nonexpressors). This study assesses the relationship between concentration-controlled...

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Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

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Source

Identifiers

PMID: 15147425
DOI: 10.1111/j.1600-6143.2004.00435.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation.PMID 15147425Read ↗

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