Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1.

doi:10.1002/humu.20039

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1.

Human mutation - 1 Jun 2004

Neville Matt J, Johnstone Elaine C, Walton Robert T

Abstract excerpt

The dopamine D2 receptor has been extensively studied in relation to alcoholism, substance abuse, and nicotine dependence. The most frequently examined polymorphism linked to this gene is the Taq1A restriction fragment length polymorphism (RFLP) (dbSNP rs1800497; g.32806C>T in GenBank AF050737.1), which has been associated with a reduction in D2 receptor density, although this is not universally accepted. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Addictive

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Chromosomes, Human, Pair 11

Share to Genetic Linkage

Share to Polymorphism, Restriction Fragment Length

Share to Protein Serine-Threonine Kinases

Share to Receptors, Dopamine D2

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 15146457
DOI: 10.1002/humu.20039

Genes

DRD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1.PMID 15146457Read ↗

Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1.Semantic proximity Read ↗

The ANKK1 kinase gene and psychiatric disorders.Semantic proximity Read ↗

Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions.Semantic proximity Read ↗

Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability.Semantic proximity Read ↗

Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample.Semantic proximity Read ↗

The addiction-susceptibility TaqIA/Ankyrin repeat and kinase domain containing 1 kinase (ANKK1) controls reward and metabolism through dopamine receptor type 2 (DR2)-expressing neuronsSemantic proximity Read ↗

Assessment of the Association of D2 Dopamine Receptor Gene and Reported Allele Frequencies With Alcohol Use DisordersSemantic proximity Read ↗

The ANKK1 protein associated with addictions has nuclear and cytoplasmic localization and shows a differential response of Ala239Thr to apomorphine.Semantic proximity Read ↗

DRD2 and ANKK1 gene polymorphisms and alcohol dependence: a case-control study among a Mendelian population of East Asian ancestry.Semantic proximity Read ↗

Dopamine D2 receptor gene Taq I 'A' locus map including 'A4' variant: relevance for alcoholism and drug abuse.Semantic proximity Read ↗

A DRD2 and ANKK1 haplotype is associated with nicotine dependence.Semantic proximity Read ↗

A genetic schizophrenia-susceptibility region located between the ANKK1 and DRD2 genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.