Article
Human CD34(+) and CD34(+)CD38(-) hematopoietic progenitors in sickle cell disease differ phenotypically and functionally from normal and suggest distinct subpopulations that generate F cells.
Experimental hematology - 1 May 2004
Luck Lori, Zeng Licheng, Hiti Alan L, Weinberg Kenneth I, Malik Punam
Abstract excerpt
OBJECTIVE: Sickle cell disease (SCD) is remarkable for stress erythropoiesis. We investigated the progenitor populations contributing to erythroid stress. MATERIALS AND METHODS: We characterized hematopoietic progenitor cells in sickle bone marrow and sickle peripheral blood from patients with SCD compared to those in normal bone marrow. RESULTS: There were increased proportions of sickle bone marrow and sickle...
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