Article
Association of HLA-DQ5 and HLA-DR1 with sensitization to organic acid anhydrides.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 May 2004
Jones M G, Nielsen J, Welch J, Harris J, Welinder H, Bensryd I, Skerfving S, Welsh K, Venables K M, Taylor A N
Abstract excerpt
BACKGROUND: Organic acid anhydrides are low molecular weight industrial chemicals, able to cause rhinoconjunctivitis and asthma associated with specific IgE against hapten-carrier protein conjugate. Only a proportion of exposed workers develop IgE-associated allergy to acid anhydrides. OBJECTIVE: We determined whether genetic susceptibility, in particular, HLA Class II alleles may be a risk factor. METHODS: We...
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