Article
HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy.
The Journal of allergy and clinical immunology - 1 Sept 2002
Rihs Hans-Peter, Chen Zhiping, Ruëff Franziska, Cremer Reinhold, Raulf-Heimsoth Monika, Baur Xaver, Moneret-Vautrin Denise Anne, Brüning Thomas
Abstract excerpt
BACKGROUND: Hevein is one of the most important latex allergens affecting health care workers (HCWs). OBJECTIVE: Because the genetically determined susceptibility is one important factor regulating type I allergy, the association between the hevein-specific IgE immune response and HLA class II alleles of DQB1 and DRB1, DRB3, DRB4, and DRB5 was studied. METHODS: The distribution of HLA-DQB1 and DRB1, DRB3, DRB4,...
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