Article
Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2004
Malo Madhu S, Zhang Wenying, Alkhoury Fuad, Pushpakaran Premraj, Abedrapo Mario A, Mozumder Moushumi, Fleming Elizabeth, Siddique Aleem, Henderson Joseph W, Hodin Richard A
Abstract excerpt
Thyroid hormone (T3) is a critical regulator of intestinal epithelial development and homeostasis, but its mechanism of action within the gut is not well understood. We have examined the molecular mechanisms underlying the T3 activation of the enterocyte differentiation marker intestinal alkaline phosphatase (IAP) gene. RT-PCR and Western blotting showed that thyroid hormone receptors TRalpha1 and TRbeta1 were...
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