Cancer: more of polygenic disease and less of multiple mutations? A quantitative viewpoint.

Abstract excerpt

The focus of cancer research is on cancer-specific mutations, with most clinical trials involving targeted drugs. Huge numbers of DNA lesions and tumor resistance events, in each of the >10¹³ cells of a human individual, form a striking contrast to the low, and also very narrow, cancer incidence window (10⁻¹ -10⁰). A detailed consideration of these quantitative observations seems to question the present paradigm,...

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