Article
Causal drift, robust signaling, and complex disease.
PloS one - 1 Jan 2015
Wagner Andreas
Abstract excerpt
The phenotype of many regulatory circuits in which mutations can cause complex, polygenic diseases is to some extent robust to DNA mutations that affect circuit components. Here I demonstrate how such mutational robustness can prevent the discovery of genetic disease determinants. To make my case, I use a mathematical model of the insulin signaling pathway implicated in type 2 diabetes, whose signaling output is...
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