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Article

Modeling the dynamics of chromosomal alteration progression in cervical cancer: A computational model.

PloS one - 1 Jan 2017

Cabrera-Becerril Augusto, Vargas-De-León Cruz, Hernández Sergio, Miramontes Pedro, Peralta Raúl

Abstract excerpt

Computational modeling has been applied to simulate the heterogeneity of cancer behavior. The development of Cervical Cancer (CC) is a process in which the cell acquires dynamic behavior from non-deleterious and deleterious mutations, exhibiting chromosomal alterations as a manifestation of this dynamic. To further determine the progression of chromosomal alterations in precursor lesions and CC, we introduce a...

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Identifiers

PMID: 28723940
DOI: 10.1371/journal.pone.0180882
PMCID: PMC5516994

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