Article
Density-dependent selection in vesicular stomatitis virus.
Journal of virology - 1 Jun 2004
Novella Isabel S, Reissig Daniel D, Wilke Claus O
Abstract excerpt
We used vesicular stomatitis virus to test the effect of complementation on the relative fitness of a deleterious mutant, monoclonal antibody-resistant mutant (MARM) N, in competition with its wild-type ancestor. We carried out competitions of MARM N and wild-type populations at different multiplicities of infection (MOIs) and initial ratios of the wild type to the mutant and found that the fitness of MARM N...
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