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Article

Context-Dependent Effects of L Domains and Ubiquitination on Viral Budding

12 May 2004

Abstract excerpt

Many enveloped viruses encode late assembly domains, or L domains, that facilitate virion egress. PTAP-type L domains act by recruiting the ESCRT-I (endosomal sorting complex required for transport I) component Tsg101, and YPXL/LXXLF-type L domains recruit AIP-1/ALIX, both of which are class E vacuolar protein sorting (VPS) factors, normally required for the generation of vesicles within endosomes. The binding...

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Identifiers

PMID: 15140952
DOI: 10.1128/jvi.78.11.5554-5563.2004

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