Article
Mutations of the T-cell receptor constant region after in utero stem cell transplantation.
Immunogenetics - 1 Jun 2004
Pirovano Silvia, Notarangelo Luigi Daniele, Valotti Monica, Ugazio Alberto G, Albertini Alberto, Imberti Luisa
Abstract excerpt
Like the immunoglobulin genes, the T-cell receptor genes are generated by rearrangements of non-contiguous genomic V, D and J regions, but unlike the immunoglobulin genes, somatic hypermutation is an infrequent event in T-cell receptor genes. Here, we describe the occurrence of spontaneous mutations in the constant regions of the T-cell receptor beta chains of T lymphocytes obtained from two babies who underwent...
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