Article
Cancer-associated genes can affect somatic intrachromosomal recombination early in carcinogenesis.
Mutation research - 4 Jun 2004
Hooker Antony M, Morley Alexander A, Tilley Wayne D, Sykes Pamela J
Abstract excerpt
The pKZ1 recombination mutagenesis model has provided a sensitive assay where we study somatic intrachromosomal recombination (SICR) as a mutation end-point. SICR is associated with non-homologous end-joining repair of double-strand breaks and can result in chromosomal inversions and deletions, both of which are common chromosomal aberrations identified in cancers. It has been difficult to study the effect of...
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