Article
FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro.
The Journal of allergy and clinical immunology - 1 May 2004
Novak Natalija, Valenta Rudolf, Bohle Barbara, Laffer Sylvia, Haberstok Jörg, Kraft Stefan, Bieber Thomas
Abstract excerpt
BACKGROUND: Atopic dermatitis (AD) is a biphasic inflammatory skin disease characterized by an initial phase predominated by T(H)2 cytokines, which switches into a second T(H)1-dominated chronic phase. Thus far, the small number of FcepsilonRI-bearing Langerhans cells (LCs) and inflammatory dendritic epidermal cells (IDECs) in the epidermis of patients with AD has hampered a detailed functional analysis and...
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