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Article

A Fibronectin Fragment Stimulates Intervertebral Disc Degeneration In Vivo

1 Oct 2003

Abstract excerpt

STUDY DESIGN: A radiographic, histologic, biochemical, and gene expression study was conducted in vivo in a rabbit model to determine the effect of injection of the N-terminal 30 kDa fibronectin fragment (Fn-f) into the intervertebral disc along with various control substances. OBJECTIVE: To determine if the Fn-f is able to induce disc degeneration in vivo. SUMMARY OF BACKGROUND DATA: Animal models of disc...

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PMID: 14560080
DOI: 10.1097/01.brs.0000096943.27853.bc

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