Article
Developmentally regulated IκB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation
27 Apr 2004
Abstract excerpt
Necrotizing enterocolitis is a devastating inflammatory condition of the intestine that occurs almost exclusively in premature newborns. Although its exact pathogenesis is unclear, we have postulated that it may result from a predisposition of the immature intestine to mount an unusually robust and damaging response to microbial infection. In support of this idea, we report that the IL-8 response of an immature...
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