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Article

Spermine induces maturation of the immature intestinal immune system in neonatal mice.

Journal of pediatric gastroenterology and nutrition - 1 Sept 1997

ter Steege J C, Buurman W A, Forget P P

Abstract excerpt

BACKGROUND: In mice, immunological adaptation of the gut to microbial and nutritional antigens occurs at weaning in parallel with biochemical and morphological maturation. Because oral administration of spermine to neonatal rats has been shown to induce biochemical and morphological maturation, we investigated whether spermine also affects maturation of the mucosal immune system. METHODS: Swiss mice 7, 12, and 27...

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Identifiers

PMID: 9285387
DOI: 10.1097/00005176-199709000-00017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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