Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel heparan sulfate mimetic compounds as antitumor agents.

Chemistry & biology - 1 Mar 2004

Ishida Keisuke, Wierzba Michal K, Teruya Takayuki, Simizu Siro, Osada Hiroyuki

Abstract excerpt

Heparan sulfate glycosaminoglycans (HSGAGs) are involved in tumor cell growth, adhesion, invasion, and migration, due to their interactions with various proteins. In this study, novel HSGAG-mimetic compounds (KI compounds) were designed and synthesized. As a result of cell-based assays, KI-105 was found to exert potent inhibitory activities against migration and invasion of human fibrosarcoma HT1080 cells. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Cell Movement
Share to Drug Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronidase

Share to Heparitin Sulfate

Share to Molecular Conformation

Share to Molecular Structure

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 15123266
DOI: 10.1016/j.chembiol.2004.02.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Novel heparan sulfate mimetic compounds as antitumor agents.PMID 15123266Read ↗

Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal CancerSemantic proximity Read ↗

A chondroitin sulfate proteoglycan 4‑specific monoclonal antibody inhibits melanoma cell invasion in a spheroid model.Semantic proximity Read ↗

Integrin αV Inhibition by GMI, a Ganoderma Microsporum Immunomodulatory Protein, Abolish Stemness and Migration in EGFR-Mutated Lung Cancer Cells Resistant to Osimertinib.Semantic proximity Read ↗

β‐mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP‐2 and MMP‐9 expression and activating the ERK and JNK pathwaysSemantic proximity Read ↗

Modulation of biological phenotypes for tumor growth and metastasis by target-specific biological inhibitors in gastric cancer.Semantic proximity Read ↗

Inhibition by Tyroserleutide (YSL) on the Invasion and Adhesion of the Mouse Melanoma CellSemantic proximity Read ↗

N-Acetylglucosaminyltransferase III Antagonizes the Effect of N-Acetylglucosaminyltransferase V on α3β1 Integrin-mediated Cell MigrationSemantic proximity Read ↗

Biological studies and potential therapeutic applications of monoclonal antibodies and small molecules reactive with the neu/c-erbB-2 protein.Semantic proximity Read ↗

Antisense-mediated suppression of Heparanase gene inhibits melanoma cell invasion.Semantic proximity Read ↗

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.Semantic proximity Read ↗

Invasive human fibrosarcoma DNA mediated induction of a 92 kDa gelatinase/type IV collagenase leads to an invasive phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.