Article
Integrin αV Inhibition by GMI, a Ganoderma Microsporum Immunomodulatory Protein, Abolish Stemness and Migration in EGFR-Mutated Lung Cancer Cells Resistant to Osimertinib.
Environmental toxicology - 1 Dec 2024
Kang Yu-Ting, Chang Hui-Yi, Hsieh Ya-Chu, Chou Chia-Hsuan, Hsin I-Lun, Ko Jiunn-Liang
Abstract excerpt
Integrins, the receptors of the extracellular matrix, are critical in the proliferation and metastasis of cancer cells. GMI, a Ganoderma microsporum immunomodulatory protein, possesses anticancer and antivirus abilities. The object of this study is to investigate the role of GMI in the integrins signaling pathway in lung cancer cells that harbor the EGFR L858R/T790M double mutation and osimertinib-resistance....
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