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Article

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression.

Acta neuropathologica communications - 31 Mar 2014

Weyer Sascha W, Zagrebelsky Marta, Herrmann Ulrike, Hick Meike, Ganss Lennard, Gobbert Julia, Gruber Morna, Altmann Christine, Korte Martin, Deller Thomas, Müller Ulrike C

Abstract excerpt

Synaptic dysfunction and synapse loss are key features of Alzheimer's pathogenesis. Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning and memory. Here, we used organotypic hippocampal cultures to investigate the specific role(s) of APP family members and their fragments for dendritic complexity and spine formation of principal neurons within the hippocampus. Whereas...

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Source

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Identifiers

PMID: 24684730
DOI: 10.1186/2051-5960-2-36
PMCID: PMC4023627

Genes

APP
APLP2
APLP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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