Article
Phosphorylation of alphaB-crystallin alters chaperone function through loss of dimeric substructure.
The Journal of biological chemistry - 2 Jul 2004
Aquilina J Andrew, Benesch Justin L P, Ding Lin Lin, Yaron Orna, Horwitz Joseph, Robinson Carol V
Abstract excerpt
Phosphorylation is the most common posttranslational modification of the alpha-crystallins in the human lens. These phosphorylated forms are not only important because of their abundance in aging lenses and the implications for cataract but also because they have been identified in patients with degenerative brain disease. By using mimics corresponding to the reported in vivo phosphorylation sites in the human...
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