Article
Precursors of colorectal carcinoma. Biopsy and biologic markers.
Cancer - 1 Sept 1992
O'Brien M J, O'Keane J C, Zauber A, Gottlieb L S, Winawer S J
Abstract excerpt
The term biologic marker (biomarker) of colorectal cancer refers in this article to an early preclinical phenotypic characteristic that relates to the risk for developing this cancer. Putative biologic markers in the normal colorectal mucosa of patients at risk include abnormal cell proliferation as determined by kinetic studies, ornithine decarboxylase activity, and polyamine synthesis. Alterations of mucin...
Topics
- Adenoma
- Biomarkers, Tumor
- Biopsy
- Colonic Polyps
- Colorectal Neoplasms
- Humans
- Phenotype
- Precancerous Conditions