Article
Antisense therapy specific to mutated K-ras gene in hamster pancreatic cancer model. Can it inhibit the growth of 5-FU and MMC-resistant metastatic and remetastatic cell lines?
In vivo (Athens, Greece) - 1 Jan 2000
Morioka Cíntia Yoko, Saito Seiji, Machado Marcel Cerqueira Cesar, Ohzawa Kouji, Kubrusly Márcia Saldanha, Cunha José Eduardo Monteiro, Watanabe Akiharu
Abstract excerpt
UNLABELLED: K-ras point mutation at codon 12 has a relationship greater than 90% with pancreatic cancer. Cancer therapy should also include the treatment of metastatic disease because it is known that the properties of metastatic cells may vary considerably from those of the primary tumor. AIM: To clarify if the same drugs, which can inhibit the tumor growth in the parental cell line, can inhibit the pancreatic...
Topics
- Animals
- Antineoplastic Agents
- Cell Line, Tumor
- Cell Transplantation
- Cricetinae
- DNA, Neoplasm
- Disease Models, Animal
- Drug Screening Assays, Antitumor
- Fluorouracil
- Genes, ras
- Liver Neoplasms, Experimental
- Male