Article
Antisense oligonucleotides specific to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2001
Nakada Y, Saito S, Ohzawa K, Morioka C Y, Kita K, Minemura M, Takahara T, Watanabe A
Abstract excerpt
BACKGROUND/AIMS: Point mutations of the K-ras gene are detected in > 90% of human pancreatic cancers and may play an important role in tumorigenesis. However, correlations between mutant K-ras and the invasive activity of the tumor have remained unclarified. METHODS: 17-merphosphorothioate antisense oligonucleotides targeting K-ras point mutations were transfected into three kinds of human pancreatic cancer cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.