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Article

Ribozyme against mutant K-ras mRNA suppresses tumor growth of pancreatic cancer.

International journal of oncology - 1 Mar 2004

Kijima Hiroshi, Yamazaki Hitoshi, Nakamura Masato, Scanlon Kevin J, Osamura R Yoshiyuki, Ueyama Yoshito

Abstract excerpt

Point mutations in the K-ras gene are observed at a high incidence in human pancreatic carcinomas. These alterations can be used as potential targets for specific ribozyme-mediated reversal of the malignant phenotype. We designed an anti-K-ras ribozyme against codon 12 of the mutant K-ras gene transcripts (GGT right curved arrow GTT), and generated a recombinant adenovirus to express the ribozyme (rAd/anti-K-ras...

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PMID: 14767540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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