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Article

Obtaining mice that carry human mitochondrial DNA transmitted to the progeny.

Molecular reproduction and development - 1 Jul 2004

Sokolova Vassilina A, Kustova Maria E, Arbuzova Natalia I, Sorokin Alexander V, Moskaliova Olesya S, Bass Mikhail G, Vasilyev Vadim B

Abstract excerpt

To study human diseases associated with mutations in mitochondrial DNA one needs an animal model in which the distribution of abnormal mtDNA and its impact on the phenotype might be followed. We isolated human mitochondria from HepG2 cell culture and microinjected them into murine zygotes, upon which those were transplanted to the pseudopregnant mice. PCR with species-specific primers allowed detecting human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15112322
DOI: 10.1002/mrd.20075

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