Correction of neutropenia by GM-CSF in patients with a large granular lymphocyte proliferation.

doi:10.1007/BF01698137

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Article

Correction of neutropenia by GM-CSF in patients with a large granular lymphocyte proliferation.

Annals of hematology - 1 Aug 1992

Mulder A B, de Wolf J T, Smit J W, van Oostveen J W, Vellenga E

Abstract excerpt

The in vivo and in vitro effects of GM-CSF were tested in four patients with large granular lymphocyte proliferation (LGLP) and severe granulocytopenia. All patients had an increased percentage of LGL cells (greater than 20%), whereas 3/4 patients demonstrated rearranged T-cell-receptor genes. An...

Topics

Adult
Aged
Biomarkers
Cell Division
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Immunophenotyping
Killer Cells, Natural
Lymphocyte Subsets
Middle Aged
Molecular Conformation
Neutropenia
Phenotype
Receptors, Antigen, T-Cell
Recombinant Proteins

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Identifiers

PMID: 1511064
DOI: 10.1007/BF01698137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1511064-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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