Article
Association of HLA-DQB1 coding region with unexplained recurrent spontaneous abortion.
Chinese medical journal - 1 Apr 2004
Wang Xi-Peng, Lin Qi-De, Lu Pei-Hua, Ma Zheng-Wen, Zhao Ai-Min
Abstract excerpt
BACKGROUND: DNA analysis has shown a lack of significant compatibility between couples affected by unexplained recurrent spontaneous abortion (URSA) compared with normal fertile couples, [8] although one study that made use of a PCR-sequence-specific oligonucleotide (SSO) method did observe evidence of significant compatibility in the HLA-DQA1 and DQB1 alleles between patients and aborted fetuses. [9] This study...
Topics
- Abortion, Habitual
- Female
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Haplotypes
- Humans
- Open Reading Frames
- Polymorphism, Genetic
- Pregnancy
