Article
Significant compatibility does not exist at the HLA-DQB gene locus in couples with unexplained recurrent abortions.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Aug 1992
Takakuwa K, Higashino M, Ueda H, Yamada K, Asano K, Yasuda M, Ishii S, Kazama Y, Tanaka K
Abstract excerpt
The polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method was used for both examining compatibility at the HLA-DQB1 gene locus and determining HLA-DQ antigen polymorphism in spouses of unexplained recurrent abortions. Genomic DNA samples were prepared from peripheral mononuclear cells from patient and control couples. Two hundred and thirty base pair fragments of the second exon of...
Topics
- Abortion, Habitual
- Base Sequence
- Female
- Genes, MHC Class II
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Histocompatibility
- Humans
- Male
- Molecular Sequence Data
- Phenotype