Article
Association of cholecystokinin-A receptor gene polymorphisms and panic disorder in Japanese.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2004
Miyasaka Kyoko, Yoshida Yuki, Matsushita Sachio, Higuchi Susumu, Shirakawa Osamu, Shimokata Hiroshi, Funakoshi Akihiro
Abstract excerpt
Several lines of evidence have suggested that naturally occurring alterations in cholecystokinin (CCK) systems could contribute to the development of panic disorder (PD). Among recent investigations, polymorphisms of the CCK and CCK-B receptor (R) genes were investigated, but the results were inconclusive. We recently cloned the genomic structures of human CCK-AR, and determined the transcriptional start site of...
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