Article
Association of the HOPA12bp allele with a large X-chromosome haplotype and positive symptom schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2004
Spinks Ruth, Sandhu Harinder K, Andreasen Nancy C, Philibert Robert A
Abstract excerpt
HOPA is a X-chromosome gene that encodes an essential nuclear receptor co-activator. Previously, we have demonstrated that an exonic polymorphism, termed HOPA(12bp), in the Opa (Opposite Paired) domain of this gene that is critical for neuronal growth and differentiation is associated with a low risk for schizophrenia. But curiously, we have also noted that all HOPA(12bp) probands have the same haplotype...
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