Article
Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidism.
American journal of medical genetics - 8 Jan 2001
Philibert R A, Sandhu H K, Hutton A M, Wang Z, Arndt S, Andreasen N C, Crowe R, Wassink T H
Abstract excerpt
HOPA is an Xq13 chromosome gene that codes for a RXR nuclear receptor co-activator. In a prior study of the genetic basis of schizophrenia, we showed that exonic polymorphisms in HOPA were associated with increased risk of schizophrenia and hypothyroidism in a large cohort of probands from New York. In an attempt to replicate these findings, we examined this relationship in a cohort of 173 schizophrenic probands...
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