Article
The association of a HOPA polymorphism with major depression and phobia.
Comprehensive psychiatry - 1 Jan 2000
Philibert Robert, Caspers Kristin, Langbehn Douglas, Troughton Edward P, Yucuis Rebecca, Sandhu Harinder K, Cadoret Remi J
Abstract excerpt
Thyroid hormone has a prominent role in the development and homeostasis of the central nervous system (CNS). Consequently, genes participating in thyroid hormone receptor (THR)-mediated signal transduction are prime candidates for neuropsychiatric illness susceptibility factors. Previously, we have associated exonic polymorphisms in a Xq13 thyroid receptor coactivator named HOPA with a modest increase in...
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