Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element.

Human molecular genetics - 15 Sept 2003

Olds Lynne C, Sibley Eric

Abstract excerpt

Lactase persistence is a heritable, autosomal dominant, condition that results in a sustained ability to digest the milk sugar lactose throughout adulthood. The majority of the world's human population experiences a decline in production of the digestive enzyme lactase-phlorizin hydrolase during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caco-2 Cells
Share to Gene Expression Regulation, Enzymologic
Share to Genes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Genes, Reporter

Share to Lactase

Share to Lactose Intolerance

Share to Luciferases

Source

Identifiers

PMID: 12915462
DOI: 10.1093/hmg/ddg244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12915462-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element.PMID 12915462Read ↗

Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture.Semantic proximity Read ↗

In Vitro Functional Analyses of Infrequent Nucleotide Variants in the Lactase Enhancer Reveal Different Molecular Routes to Increased Lactase Promoter Activity and Lactase Persistence.Semantic proximity Read ↗

The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity.Semantic proximity Read ↗

Lactose digestion and the evolutionary genetics of lactase persistence.Semantic proximity Read ↗

Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry.Semantic proximity Read ↗

The human lactase persistence-associated SNP -13910*T enables in vivo functional persistence of lactase promoter-reporter transgene expression.Semantic proximity Read ↗

Molecular genetics of adult-type hypolactasia.Semantic proximity Read ↗

The -13914G>A variant upstream of the lactase gene (LCT) is associated with lactase persistence/non-persistence.Semantic proximity Read ↗

A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?Semantic proximity Read ↗

13915*G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1.Semantic proximity Read ↗

Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals.Semantic proximity Read ↗

PCR-RFLP genotyping assay for a lactase persistence polymorphism upstream of the lactase-phlorizin hydrolase gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.