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Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads

22 Apr 2004

Abstract excerpt

BACKGROUND: To investigate how long fetal germ cells retain pluripotency, which may be linked to their ability to transform into histologically variable tumours, we examined the expression of OCT-3/4 (POU5F1), a transcription factor essential for the maintenance of totipotency in embryonic stem cells. METHODS: The ontogeny of expression of OCT-3/4 was studied in 74 specimens of normal human gonads during...

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PMID: 15105401
DOI: 10.1093/humrep/deh265

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