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Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications

7 Feb 2008

Abstract excerpt

Combined action of SOX and POU families of transcription factors plays major roles in embryonic development. In embryonic stem cells, the combination of SOX2 and POU5F1 (OCT3/4) is essential for maintaining the undifferentiated state by activating pluripotency-linked genes, and inhibition of genes involved in differentiation. Besides embryonic stem cells, POU5F1 is also present in early germ cells, primordial...

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PMID: 18348160
DOI: 10.1002/path.2332

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