Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin.

doi:10.1128/AAC.48.5.1630-1639.2004

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Article

Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin.

Antimicrobial agents and chemotherapy - 1 May 2004

Kaczmarek Frank S, Gootz Thomas D, Dib-Hajj Fadia, Shang Wenchi, Hallowell Shawn, Cronan Melissa

Abstract excerpt

Previous studies with beta-lactamase-negative, ampicillin-resistant (BLNAR) Haemophilus influenzae from Japan, France, and North America indicate that mutations in ftsI encoding PBP3 confer ampicillin MICs of 1 to 4 micro g/ml. Several BLNAR strains with ampicillin MICs of 4 to 16 micro g/ml recently isolated from North America were studied. Pulsed-field gel electrophoresis identified 12 unique BLNAR strains;...

Topics

Ampicillin
Ampicillin Resistance
Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Bacterial Proteins
Carrier Proteins
Cloning, Molecular
Culture Media
DNA Primers
DNA, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Electrophoresis, Gel, Pulsed-Field

Erythromycin

Haemophilus influenzae

Hexosyltransferases

Microbial Sensitivity Tests

Microscopy, Electron, Scanning

Muramoylpentapeptide Carboxypeptidase

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 15105114
DOI: 10.1128/AAC.48.5.1630-1639.2004
PMCID: PMC400547

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