Article
Differentiation of antigen-presenting cells (dendritic cells and macrophages) for therapeutic application in patients with lymphoma.
Leukemia - 1 Sept 2000
Chaperot L, Chokri M, Jacob M C, Drillat P, Garban F, Egelhofer H, Molens J P, Sotto J J, Bensa J C, Plumas J
Abstract excerpt
The recent clinical trial in lymphoma using tumor antigen-loaded DCs (Hsu et al, Nature Med 1996; 2: 52) demonstrates the efficiency of the use of professional antigen presenting cells (APCs) for taking up, processing and presenting tumor protein in a vaccine strategy in cancer. However, the production of large quantities of clinical grade APCs remains to be resolved. Here, we describe that both dendritic cells...
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