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Article

Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane.

The Journal of biological chemistry - 2 Jul 2004

Xie Jun, Guo Qing

Abstract excerpt

CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter. Par-4 (prostate apoptosis response-4) is a leucine zipper protein involved in neuronal degeneration and cholinergic signaling in Alzheimer's disease. We now report that Par-4 is a negative r...

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Identifiers

PMID: 15090548
DOI: 10.1074/jbc.M401495200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15090548-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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