Access to the carbamate tunnel of carbamoyl phosphate synthetase.

doi:10.1016/j.abb.2004.02.031

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Article

Access to the carbamate tunnel of carbamoyl phosphate synthetase.

Archives of biochemistry and biophysics - 1 May 2004

Kim Jungwook, Raushel Frank M

Abstract excerpt

The X-ray crystal structure of carbamoyl phosphate synthetase (CPS) from Escherichia coli revealed the existence of a molecular tunnel that has been proposed to facilitate the translocation of reaction intermediates between remotely located active sites. Five highly conserved glutamate residues, including Glu-25, Glu-383, Glu-577, Glu-604, and Glu-916, are close together in two clusters in the interior wall of...

Topics

Arginine
Carbamates
Carbon-Nitrogen Ligases
Escherichia coli
Glutamic Acid
Mutation
Protein Structure, Tertiary

Source

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Identifiers

PMID: 15081891
DOI: 10.1016/j.abb.2004.02.031

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