Article
The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential.
Oncogene - 20 Jul 1995
Tsuda T, Marinetti M R, Masuelli L, Cutler M L
Abstract excerpt
Rsu-1, which was isolated based on its ability to suppress transformation by v-Ras, is a highly conserved gene which shares homology with yeast adenylyl cyclase in the region required for activation by Ras. Genomic DNA clones of human RSU-1 have been isolated and used as a probe for fluorescence in situ hybridization (FISH) to assign RSU-1 to 10p13, confirming the previous results of somatic cell hybrid mapping...
Topics
- Animals
- Cadmium
- Cell Division
- Cell Transformation, Neoplastic
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- Cricetinae
- DNA, Complementary
- Gene Expression
- Genes, Tumor Suppressor
- Genes, ras