Article
Stress response induced by DNA damage leads to specific, delayed and untargeted mutations.
Molecular & general genetics : MGG - 1 Aug 1992
Boesen J J, Stuivenberg S, Thyssens C H, Panneman H, Darroudi F, Lohman P H, Simons J W
Abstract excerpt
Cells of the mouse T-lymphoma line GRSL13 were treated with 8-methoxy-psoralen plus longwave ultraviolet light (PUVA) under conditions where the biological effects are mainly due to non-persistent DNA cross-links (PUVA-CL treatment). Fluctuation analysis showed that PUVA-CL treatment resulted in...
Topics
- Animals
- Base Sequence
- DNA
- DNA Damage
- Dose-Response Relationship, Radiation
- Flow Cytometry
- Hypoxanthine Phosphoribosyltransferase
- Male
- Methoxsalen
- Mice
- Molecular Sequence Data
- Mutagenesis
- Mutagenicity Tests
- Mutation
- Tumor Cells, Cultured
- Ultraviolet Rays