Article
Characterization of a novel regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciens
1 Jul 1992
Abstract excerpt
A key step in the biosynthesis of macrolide antibiotics is the assembly of a large macrocyclic lactone ring by a multienzyme protein complex called the polyketide synthase. In the species Streptomyces ambofaciens, the polyketide synthase for the assembly of the 16-membered ring of the macrolide antibiotic spiramycin is encoded by the biosynthetic gene srmG. Here we show that the accumulation of transcripts from...
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