Article
Single nucleotide polymorphisms in the interferon-gamma and interleukin-10 genes do not influence chronic hepatitis C severity or T-cell reactivity to hepatitis C virus.
Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2004
Abbott William G H, Rigopoulou Eirini, Haigh Philip, Cooksley Helen, Mullerova Ivana, Novelli Marco, Winstanley Alison, Williams Roger, Naoumov Nikolai V
Abstract excerpt
BACKGROUND: The mechanisms by which interferon-gamma (IFN-gamma) contributes to inter-individual heterogeneity in the severity of chronic hepatitis C (CH-C) are unknown. In 116 consecutive patients with CH-C, we tested the hypothesis that host genetic factors regulating IFN-gamma production and activity influence the severity of liver damage and hepatitis C virus (HCV)-specific T-cell reactivity. METHODS: We...
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