Article
Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity.
The Journal of surgical research - 1 Jan 2004
Kalady Matthew F, Onaitis Mark W, Emani Sirisha, Abdel-Wahab Zeinab, Tyler Douglas S, Pruitt Scott K
Abstract excerpt
BACKGROUND: Despite the increasing use of dendritic cells (DCs) in clinical trials, questions regarding the optimal means of DC preparation, in particular how to achieve optimal maturation, remain unanswered. We hypothesized that delivering two separate sequential maturation signals to DC in vitro, mimicking the process of DC maturation that occurs in vivo, would enhance the ability of DCs to generate...
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