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Article

Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function.

Biochemical and biophysical research communications - 2 Apr 2004

Terada Tomohiro, Irie Megumi, Okuda Masahiro, Inui Ken-ichi

Abstract excerpt

We evaluated the functional consequences of genetic variations in human H(+)/peptide cotransporter 2 (hPEPT2, SLC15A2) resulting in the amino acid changes Arg57His (R57H) and Pro409Ser (P409S). The transport activity of variant R57H was completely abolished, whereas that of variant P409S was comparable with that of wild-type hPEPT2 at pH 5.0-8.0. R57H variant protein was detected in the crude membranes of...

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PMID: 15020234
DOI: 10.1016/j.bbrc.2004.02.063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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