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Article

Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment

15 Apr 2004

Abstract excerpt

Hedgehog (Hh) signalling controls many aspects of development. It also regulates cell growth and differentiation in adult tissues and is activated in a number of human malignancies. Hh and Wnt signalling frequently act together in controlling cell growth and tissue morphogenesis. Despite the fact that the majority of colorectal tumours have a constitutively activated canonical Wnt pathway, few previous studies...

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PMID: 15170664
DOI: 10.1002/ijc.20227

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